The main objective of the study is to measure how safe and effective BT8009 (zelenectide pevedotin) is when used alone and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC).

The purpose of this clinical trial is to assess whether a medical device called the TIVUS System can lower high blood pressure in patients who are known to have hypertension. 

Eligible patients include those who currently have a diagnosis of high blood pressure despite having taken or currently taking anti-hypertensive medications.

The purpose of this clinical study is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication.

Eligible patients include those who currently have a diagnosis of high blood pressure despite having taken or are currently taking anti-hypertensive medications.