The Institute for Plastic Surgery maintains its own Office for Clinical Research. This office supports the division’s efforts to conduct clinical studies and clinical trials initiated by an industry sponsor or by the division’s faculty. Ongoing studies include the following: Patients with Raynaud’s Syndrome Sought for SIU Clinical Trial Patients suffering with finger pain caused by Raynaud’s Syndrome are needed to participate in a clinical trial at Southern Illinois University School of Medicine’s Institute for Plastic Surgery. The randomized, double-blind clinical trial examines the effect of

Reuben A. Bueno, MD Professor and Chief, Division of Plastic Surgery Nicole Z. Sommer, MD Associate Professor, Residency Program Director, Director of Cosmetic Clinic Nada Berry, MD Assistant Professor Brian Mailey, MD Assistant Professor, Vice Chair of Research, Director of Brachial Plexus and Tetraplegia Clinic Michael Neumeister, MD Professor and Chairman, Department of Surgery, Director of Hand Fellowship Program __ Carrie Harrison, BS Research Laboratory Coordinator Education : 1998 - BS, Clinical Laboratory Science, University of Illinois Springfield Email: charrison@siumed.edu Phone

Published work highlighting tissue engineering efforts of the Basic Science Lab Lough DM, Yang M, Blum A, Reichensperger JD, Cosenza NM, Wetter N, Cox LA, Harrison CE, Neumeister MW. Transplantation of the LGR6+ Epithelial Stem Cell Into Full-Thickness Cutaneous Wounds Results in Enhanced Healing, Nascent Hair Follicle Development, and Augmentation of Angiogenic Analytes. Plast Reconstr Surg. 2014 MAR;133(3):579-90 DOI:10.1097/PRS. 0000000000000075. PubMed PMID: 24572851. Derby BM, Dai H, Reichensperger J, Cox L, Harrison C, Cosenza N, Yang M, Bueno RA, Neumeister MW. Adipose-Derived Stem Cell

1. New Antimicrobial Agents to Eradicate Infection and Sterilize Burn Wounds The ability to utilize antimicrobial peptides for the prevention of burn wound infections may significantly reduce infection rates and thus, mortality in high-risk patients. We are measuring the ability of antimicrobial peptides to sterilize burn wounds in an animal model. Success in this experiment may justify further experiments in a clinical setting. The long-term goal is to use these compounds as a better alternative to topical antibiotics to eradicate microorganisms in burn wounds. 2. ADSC Transplantation

The long-term goal of the Laboratory for Regenerative Medicine and Applied Sciences is to develop a functional hybrid graft to heal full-thickness skin defects and explore the potential of epithelial-derived stem cells (LGR5+ and LGR6+) for burns, neuropathic ulcers, and hair regeneration. We are also exploring the potential of merging TRAIL (TNF-Related Apoptosis-Inducing Ligand) therapy with conventional breast reconstruction procedures to eliminate breast cancer recurrence after mastectomy.

The United States is in the midst of an opioid overdose epidemic. Opioids (including prescription opioids and heroin) killed more than 33,000 people in 2015, more than any year on record, according to the Centers for Disease Control and Prevention. Nearly half of all opioid overdose deaths involve a prescription pain reliever. More Illinoisans die from opioid drug overdoses than from motor vehicle accidents or all gun-related causes. An educational conference will address issues surrounding the opioid prescription drug and heroin epidemic, starting at 8:30 a.m. on June 6 at the Mount Vernon

American Society for Reconstructive Transplantation International Hand and Composite Tissue Allotransplantation Society Memorial Transplant Services Memorial Medical Center Foundation Gift of Hope Mid-America Transplant Services Indiana Donor Network Donate Life Life Goes On

The Institute for Plastic Surgery at Southern Illinois University School of Medicine , in partnership with Memorial Medical Center, is conducting a clinical trial of hand and upper extremity transplantation for patients who have previously lost one or both hands/arms. The Hand and Arm Transplant program was approved by the Springfield Committee for Research Involving Human Subjects on October 17th, 2013 (IRB protocol # 12-811) and is currently enrolling patients interested in hand transplantation. Click on the tabs above and to the left of the page for more information. Hand Transplantation

Institute for Plastic Surgery Physical Address: Baylis Medical Building, 747 North Rutledge Street, 3rd Floor, Springfield, IL 62702 Mailing Address: P.O. Box 19653, Springfield, IL 62794-9653 Administrative Phone : 217- 545-2588 Patient Appointment: 217-545-6314 Clinical Fax: 217-545-7011 Email : plastics@siumed.edu