Trial
Neurology

Xenon XPF-010-302: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

Active recruiting
The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.
Contact: Stephanie Kohlrus 217-545-3013
Trial
Neurology

UCB EP0165: An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

Active recruiting
The primary endpoint of this study is to evaluate the long-term safety and tolerability of Staccato alprazolam.
Contact: Rylee Manka 217-545-1394
Trial
Neurology

UCB EP0162: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Outpatient, Parallel-Group Study to Assess the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

Active recruiting
The purpose of this study is to compare the success of a single admnistration of Staccato alprazolam compared with placebo in rapidly terminating a seizure episode within 90seconds after IMP administration.
Contact: Rylee Manka 217-545-1394
Trial
Neurology

Supernus Renaissance 2: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of SPN-817 in Adults with Focal Onset Seizures

Active recruiting

To evaluate the efficacy of SPN-817 as a treatment for adult participants with focal onset seizures.

Contact: Stephanie Kohlrus 217-545-3013
Trial
Neurology

ADCS Benfo: A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients with Early Alzheimer’s Disease (BenfoTeam)

Active recruiting
The purpose of this study is to learn more about the safety, effectiveness and tolerability of the study drug called Benfotiamine, to determine whether it delays or slows the progression of the symptoms of early Alzheimer’s disease.
Contact: Stephanie Kohlrus 217-545-3013
Trial
Internal Medicine

RECHARGE

Active recruiting

Trial Objective: To compare the long-term effects of percutaneous coronary intervention (PCI) (i.e., stenting) versus coronary artery bypass grafting (CABG) (i.e., open-heart surgery) in women and minorities.

You may be eligible to participate if you:

  • Are a woman and/or are Black or Hispanic
  • And planning to receive a heart stent (PCI) or open-heart surgery (CABG) to treat blocked arteries
Contact: Katie Mottershaw 217-545-7387
Trial
Internal Medicine

RECHARGE

Active recruiting

Trial Objective: To compare the long-term effects of percutaneous coronary intervention (PCI) (i.e., stenting) versus coronary artery bypass grafting (CABG) (i.e., open-heart surgery) in women and minorities.

You may be eligible to participate if you:

  • Are a woman and/or are Black or Hispanic
  • And planning to receive a heart stent (PCI) or open-heart surgery (CABG) to treat blocked arteries
Contact: Katie Mottershaw 217-545-7387
General Results

Neural Basis of Decisions current lab projects

Algorithmic basis of reward-based decisions in dynamic environment In probabilistic reward foraging task (Fig.1A) animals’ choices tend to reflect the previous rewards, in a way that biases animals’ future choices to options from which they recently received the rewards. In addition to the reward history effects, curiously animals choices also depend on the previous choices, phenomenon that is not easily explained by the current computational models (Fig.1B). We are formulating normative accounts of why choice history effects should persist in animals. The insight into this phenomenon may give
News

SIU medical student awarded national research fellowship for work on cancer-fighting immune cells

SPRINGFIELD, Ill. – Anjali Patel, a second-year medical student at Southern Illinois University School of Medicine, has been selected for the 2025 Carolyn L. Kuckein Student Research Fellowship by the Alpha Omega Alpha Honor Medical Society. The nationally competitive award supports medical students conducting original research in areas that advance clinical medicine and patient care. Patel’s project explores a novel approach to enhancing the effectiveness of natural killer (NK) cells in treating solid tumors. Her research aims to prevent immune suppression in the tumor environment by blocking
News

SIU medical student awarded national research fellowship for work on cancer-fighting immune cells

SPRINGFIELD, Ill. – Anjali Patel, a second-year medical student at Southern Illinois University School of Medicine, has been selected for the 2025 Carolyn L. Kuckein Student Research Fellowship by the Alpha Omega Alpha Honor Medical Society. The nationally competitive award supports medical students conducting original research in areas that advance clinical medicine and patient care. Patel’s project explores a novel approach to enhancing the effectiveness of natural killer (NK) cells in treating solid tumors. Her research aims to prevent immune suppression in the tumor environment by blocking
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