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Hospitalization Among Patients with Schizophrenia Spectrum Disorders (SSD) Investigators Obiora Onwuameze, MD (Faculty, Adult Division) Vinod Alluri, MD (Faculty, Adult Division) Objective: The objectives of this project are to 1) Determine the relationship between depression and hospitalization in patients with SSDs; 2) evaluate psychotic symptoms as a predictor of hospitalization in SSDs patients; 3) assess diagnosis of schizophrenia versus schizoaffective disorder as a predictor of hospitalization in SSD patients; and 4) develop a preliminary predictive model of variables for

FIRST (Family Intervention in Recent Onset Schizophrenia Trial) Investigators Jeffrey I. Bennett, MD (Faculty, Adult Division) Obiora Onwuameze, MD (Faculty, Adult Division) Vinod Alluri, MD (Faculty, Adult Division) This observational study compares outcomes for caregivers of patients with new onset schizophrenia, schizoaffective disorder, or schizophreniform disorder who receive a program of online psychoeducational training versus support as usual. Caregiver health status, patient outcomes, satisfaction, and various subjective parameters will be measured over a 12-month period. Patients

ASPIRE (A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of intranasal esketamine in addition to comprehensive standard of care for the rapid reduction of the symptoms of major depressive disorder, including suicidal ideation, in subjects assessed to be at imminent risk for suicide) Investigators Jeffrey I. Bennett, MD (Faculty, Adult Division) Vinod Alluri, MD (Faculty, Adult Division) Michelle Gates, PhD (Faculty, Division of Clinical Psychology) Santosh Shrestha, MD (Faculty, Adult Division) Arindam Chakrabarty, MD (Resident) Background: Major

45 CFR 46 Protection of Human Subjects The HHS (OHRP) regulations, 45 CFR part 46 , include four subparts: subpart A, also known as the Federal Policy or the “Common Rule”; subpart B, additional protections for pregnant women, human fetuses, and neonates; subpart C, additional protections for prisoners; and subpart D, additional protections for children. 45 CFR 164 Disclosures for Public Health Activities The Privacy Rule, HIPAA. 21 CFR 50 Protection of Human Subjects (FDA) 21 CFR 50 Include the regualtions for the protection of human research subjects. In many ways, identical to 45 CFR 46. 21

OBSERVEMDD0001 (A prospective, longitudinal, observational study to evaluate potential predictors of relapse in subjects with major depressive disorder who have responded to antidepressant treatment) Investigators : Jeffrey I. Bennett, MD (Faculty, Adult Division) Obiora Onwuameze, MD (Faculty, Adult Division) Vinod Alluri, MD (Faculty, Adult Division) Eric Black, MD (Faculty, Adult Division) Santosh Shrestha, MD (Faculty, Adult Division) Arindam Chakrabarty, MD (Resident) This multisite, industry sponsored study investigates measurable parameters predicting relapse in recurrent Major

Welcome to the Department of Medical Microbiology, Immunology and Cell Biology. We are one of 15 departments comprising the SIU School of Medicine in Springfield, the capital city of Illinois. Our department consists of talented energetic faculty, each actively involved in discovery-based biomedical research and committed to the education and training of graduate and medical students at the School of Medicine. We have new and renovated laboratories and state of the art equipment which enables innovative research into clinically significant fields such as: mechanisms promoting tumor growth and

Our researchers are working on dozens of projects covering the following areas: Molecular Oncology, Tumor Marker, and Experimental Therapeutics Immune sytems role in the reproductive process ototoxicity and otoprotective agents Molecular Oncology Endothelial Cell Biology and Tumor Physiology Staphylococcus aureus Gene Therapy