Effective date: May 22, 2015 Re: Payment of IRB Review Fee If you are submitting a protocol for IRB review at Southern Illinois University School of Medicine, and the Clinical Trial Agreement (CTA) is not executed at the time of submission, the IRB requires documentation from the Sponsor stating that the Sponsor agrees to pay the IRB review fee regardless of the CTA negotiation outcome. Without this documentation, the protocol cannot be placed on an IRB meeting agenda for review until the CTA is executed. Furthermore, if a protocol is reviewed by the IRB prior to CTA execution, language